MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2619 to 2667 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	chaperone binding	molecular function
			cytoplasm	cellular component
			cytoskeleton
			microtubule
			microtubule cytoskeleton organization and biogenesis	biological process
			protein binding	molecular function
			protein folding	biological process
			protein modification process
6.3909		Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	apoptosis
			cytoplasm	cellular component
			intracellular signaling cascade	biological process
			metal ion binding	molecular function
			negative regulation of cell growth	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			response to stress
			transcription
			zinc ion binding	molecular function
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	ATP binding
			magnesium ion binding
			nucleotide binding
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	DNA-directed RNA polymerase activity
			DNA-directed RNA polymerase III complex	cellular component
			nucleoplasm
			nucleus
			protein binding	molecular function
			transcription	biological process
			transcription from RNA polymerase III promoter
7.27043	up	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]	lipid binding	molecular function
7.45006	down	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	G-protein coupled receptor protein signaling pathway	biological process
			histamine receptor activity	molecular function
			integral to membrane	cellular component
			structural constituent of cell wall	molecular function
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	catalytic activity
			cofactor binding
			cytoplasm	cellular component
			defense response	biological process
			DNA binding	molecular function
			humoral immune response	biological process
			nucleus	cellular component
			oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular function
			translation regulator activity
			ubiquitin cycle	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.