MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.48389	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	cellular component	intracellular
			nuclear pore
			nucleus
			proton-transporting two-sector ATPase complex
		molecular function	ATP binding
			DNA binding
			hydrogen ion transporting ATP synthase activity, rotational mechanism
			hydrogen ion transporting ATPase activity, rotational mechanism
			metal ion binding
			protein binding
			transporter activity
			zinc ion binding
1.49271	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	biological process	cell cycle
			DNA repair
			ubiquitin cycle
		cellular component	cellular_component
		molecular function	molecular_function
			protein binding
1.49558	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	biological process	BMP signaling pathway
			bone mineralization
			cardiac cell differentiation
			cartilage development
			cell fate commitment
			cell growth
			cell-cell signaling
			embryonic development
			epithelial to mesenchymal transition
			growth
			inflammatory response
			negative regulation of cell proliferation
			negative regulation of progression through cell cycle
			odontogenesis (sensu Vertebrata)
			organ morphogenesis
			osteoblast differentiation
			positive regulation of astrocyte differentiation
			positive regulation of ossification
			positive regulation of osteoblast differentiation
			regulation of transcription
			ureteric bud branching
		cellular component	extracellular region
			extracellular space
		molecular function	cytokine activity
			growth factor activity
			protein binding
			transforming growth factor beta receptor binding
1.49923	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	biological process	blood vessel development
			cell-cell adhesion
			platelet-derived growth factor receptor signaling pathway
			regulation of small GTPase mediated signal transduction
			signal transduction

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.