Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 50 of 91 in total
Class  : cellular component
Gene Ontology  : nucleus
Ratio
Regulation
description
8.21788 up Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]
6.56408 down DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]
6.3909 Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]
5.83544 Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]
5.81102 up PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]
5.32612 down Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
4.55371 up Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
4.55177 Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]
4.49282 down Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]
4.4149 X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]
4.14557 Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]
4.14054 up Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]
4.04651 Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
3.83977 down AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]
3.81736 up Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
3.71868 down Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]
3.70292 up Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
3.62109 down Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]
3.48313 Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]
3.43019 Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]
3.36725 up TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]
3.35536 RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]
3.29064 down Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
3.27919 Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
2.96739 up Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]
2.95579 Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]
2.91954 Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]
2.87038 Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]
2.86965 RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]
2.86298 T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]
2.83611 down SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]
2.72371 up Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]
2.7017 Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
2.58329 down Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]
2.31039 up STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]
2.29381 Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]
2.12709 down Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]
2.10428 up Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
1.98137 down Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]
1.93995 up Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Uniprot/SWISSPROT;Acc:Q92785]
1.89168 down Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]
1.86204 Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]
1.81557 Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]
1.78708 up Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]
1.78439 Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
1.73211 down Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
1.69345 up GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
1.683 down Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
1.66679 up TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]
1.65835 down Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/