MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1301 to 1350 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.17879	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	biological process	ion transport
			potassium ion transport
			sensory perception of sound
		cellular component	membrane
			membrane fraction
			voltage-gated potassium channel complex
		molecular function	ion channel activity
			potassium ion binding
			voltage-gated ion channel activity
			voltage-gated potassium channel activity
1.18263	Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3). [Uniprot/SWISSPROT;Acc:Q8TAT2]		growth factor binding
1.18489	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	biological process	cGMP biosynthetic process
			cyclic nucleotide biosynthetic process
			intracellular signaling cascade
		cellular component	cytoplasm
		molecular function	guanylate cyclase activity
			heme binding
			iron ion binding
			metal ion binding
			phosphorus-oxygen lyase activity
1.18711	NULL		protein binding
1.19117	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	biological process	G-protein coupled receptor protein signaling pathway
			transport
		cellular component	cytoplasm
			nucleus
		molecular function	GTP binding
			guanyl nucleotide binding
			nucleotide binding
			protein binding
			signal transducer activity
1.19207	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	biological process	mRNA export from nucleus
			multicellular organismal development
			transport
		cellular component	cytoplasm
			intracellular
			nuclear RNA export factor complex
			nucleus
		molecular function	nucleotide binding
			protein binding
			RNA binding
1.19496	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	biological process	carbohydrate metabolic process
			glutathione metabolic process
			glyoxylate cycle
			isocitrate metabolic process
			metabolic process
			response to oxidative stress
			tricarboxylic acid cycle
		cellular component	cytoplasm
			cytosol
			peroxisome

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.