Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio description Regulation Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 41 of 41 in total

Class	biological process
Gene Ontology	regulation of transcription, DNA-dependent

Ratio	description	Regulation	
1.10889	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	up	
1.1243	Zinc finger protein basonuclin-2. [Source:Uniprot/SWISSPROT;Acc:Q6ZN30]	down	
1.13007	Zinc finger protein 219. [Source:Uniprot/SWISSPROT;Acc:Q9P2Y4]	up	
1.16921	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Source:Uniprot/SWISSPROT;Acc:Q96HZ4]	up	
1.22576	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	up	
1.25113	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Source:Uniprot/SWISSPROT;Acc:Q15072]	down	
1.25808	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	up	
1.27461	Homeobox protein Hox-D3 (Hox-4A). [Source:Uniprot/SWISSPROT;Acc:P31249]	down	
1.28356	T-box transcription factor TBX2 (T-box protein 2). [Source:Uniprot/SWISSPROT;Acc:Q13207]	down	
1.30082	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Source:Uniprot/SWISSPROT;Acc:Q9NZN8]	down	
1.30407	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Source:Uniprot/SWISSPROT;Acc:O15522]	up	
1.33465	T-box transcription factor TBX5 (T-box protein 5). [Source:Uniprot/SWISSPROT;Acc:Q99593]	up	
1.44789	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	up	
1.45148	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	up	
1.45624	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	up	
1.50206	LAG1 longevity assurance homolog 4. [Source:Uniprot/SWISSPROT;Acc:Q9HA82]	up	
1.57088	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Source:Uniprot/SWISSPROT;Acc:O15409]	up	
1.59188	Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Source:Uniprot/SWISSPROT;Acc:Q8TF68]	up	
1.60746	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Source:Uniprot/SWISSPROT;Acc:Q8TD26]	down	
1.66123	KRAB-A domain containing 1 (KRBA1), mRNA [Source:RefSeq_dna;Acc:NM_032534]	up	
1.69345	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Source:Uniprot/SWISSPROT;Acc:P16383]	up	
1.86204	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Source:Uniprot/SWISSPROT;Acc:Q8NAM6]	down	
1.89168	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Source:Uniprot/SWISSPROT;Acc:O95125]	down	
1.93995	Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Source:Uniprot/SWISSPROT;Acc:Q92785]	up	
1.98137	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Source:Uniprot/SWISSPROT;Acc:P35398]	down	
2.10428	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Source:Uniprot/SWISSPROT;Acc:P05412]	up	
2.31039	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Source:Uniprot/SWISSPROT;Acc:O94864]	up	
2.58329	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Source:Uniprot/SWISSPROT;Acc:Q9UL68]	down	
2.83611	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Source:Uniprot/SWISSPROT;Acc:Q9UJW9]	down	
2.86298	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Source:Uniprot/SWISSPROT;Acc:Q16650]	up	
3.29064	Transcription factor GATA-6 (GATA-binding factor 6). [Source:Uniprot/SWISSPROT;Acc:Q92908]	down	
3.35536	RNA polymerase-associated protein RTF1 homolog. [Source:Uniprot/SWISSPROT;Acc:Q92541]	up	
3.48313	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Source:Uniprot/SWISSPROT;Acc:Q9GZN2]	down	
3.70292	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Source:Uniprot/SWISSPROT;Acc:Q9UIU6]	up	
3.81736	Transcription factor E2F3 (E2F-3). [Source:Uniprot/SWISSPROT;Acc:O00716]	up	
4.04651	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Source:Uniprot/SWISSPROT;Acc:Q9UH99]	up	
4.4149	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Source:Uniprot/SWISSPROT;Acc:P17861]	down	
4.49282	Enhancer of polycomb homolog 1. [Source:Uniprot/SWISSPROT;Acc:Q9H2F5]	down	
4.55177	Transcription factor SOX-14. [Source:Uniprot/SWISSPROT;Acc:O95416]	up	
5.32612	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Source:Uniprot/SWISSPROT;Acc:Q12968]	down	
6.3909	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	down	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/