Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 66 in total

Class	cellular component
Gene Ontology	cytoplasm

Ratio	Regulation	description	
1.10233	up	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Source:Uniprot/SWISSPROT;Acc:Q99501]	
1.10889	up	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [Source:RefSeq_dna;Acc:NM_001099408]	
1.14311	down	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	
1.17693	up	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Source:Uniprot/SWISSPROT;Acc:Q9H4M7]	
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Source:Uniprot/SWISSPROT;Acc:P35354]	
1.18489	up	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Source:Uniprot/SWISSPROT;Acc:O75343]	
1.19117	up	Ras-related GTP-binding protein D (Rag D). [Source:Uniprot/SWISSPROT;Acc:Q9NQL2]	
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Source:Uniprot/SWISSPROT;Acc:Q9GZY0]	
1.19496	up	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Source:Uniprot/SWISSPROT;Acc:O75874]	
1.19539	up	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Source:Uniprot/SWISSPROT;Acc:Q9Y697]	
1.20924	down	Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Source:Uniprot/SWISSPROT;Acc:P47895]	
1.21705	up	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Source:Uniprot/SWISSPROT;Acc:P78371]	
1.22178	up	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Source:Uniprot/SWISSPROT;Acc:O94921]	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	
1.28319	up	Autophagy-related protein 10 (APG10-like). [Source:Uniprot/SWISSPROT;Acc:Q9H0Y0]	
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Source:Uniprot/SWISSPROT;Acc:O75122]	
1.29952	down	Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Source:Uniprot/SWISSPROT;Acc:Q9UBF1]	
1.30082	down	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Source:Uniprot/SWISSPROT;Acc:Q9NZN8]	
1.30207	down	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Source:Uniprot/SWISSPROT;Acc:Q5SW96]	
1.33465	up	T-box transcription factor TBX5 (T-box protein 5). [Source:Uniprot/SWISSPROT;Acc:Q99593]	
1.33817	down	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Source:Uniprot/SWISSPROT;Acc:Q9H0R8]	
1.36997	up	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Source:Uniprot/SWISSPROT;Acc:Q8N264]	
1.37801	up	Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Source:Uniprot/SWISSPROT;Acc:Q9HCC8]	
1.40602	up	GTP-binding protein SAR1a (COPII-associated small GTPase). [Source:Uniprot/SWISSPROT;Acc:Q9NR31]	
1.40749	up	collagen, type XXVII, alpha 1 [Source:RefSeq_peptide;Acc:NP_116277]	
1.42264	up	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Source:Uniprot/SWISSPROT;Acc:Q9BWF3]	
1.45635	up	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	
1.5415	down	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Source:Uniprot/SWISSPROT;Acc:Q86SQ0]	
1.55809	down	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Source:Uniprot/SWISSPROT;Acc:Q14442]	
1.59763	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Source:Uniprot/SWISSPROT;Acc:Q8WVN8]	
1.61673	up	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Source:Uniprot/SWISSPROT;Acc:Q6P2M8]	
1.65835	down	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Source:Uniprot/SWISSPROT;Acc:P57772]	
1.683	down	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Source:Uniprot/SWISSPROT;Acc:Q9Y2L1]	
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Source:Uniprot/SWISSPROT;Acc:Q9H1R3]	
1.73211	down	Antigen KI-67. [Source:Uniprot/SWISSPROT;Acc:P46013]	
1.74736	down	Proline-serine-threonine phosphatase-interacting protein 2. [Source:Uniprot/SWISSPROT;Acc:Q9H939]	
1.83496	up	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Source:Uniprot/SWISSPROT;Acc:Q92636]	
1.93995	up	Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Source:Uniprot/SWISSPROT;Acc:Q92785]	
2.07532	up	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Source:Uniprot/SWISSPROT;Acc:Q9Y566]	
2.11557	down	Echinoderm microtubule-associated protein-like 5 (EMAP-5). [Source:Uniprot/SWISSPROT;Acc:Q05BV3]	
2.20843	up	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Source:Uniprot/SWISSPROT;Acc:P07947]	
2.25955	down	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Source:Uniprot/SWISSPROT;Acc:Q9BW92]	
2.29381	up	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Source:Uniprot/SWISSPROT;Acc:O15265]	
2.2939	up	Hermansky-Pudlak syndrome 3 protein. [Source:Uniprot/SWISSPROT;Acc:Q969F9]	
2.31699	down	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Source:Uniprot/SWISSPROT;Acc:P62714]	
2.75351	up	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Source:Uniprot/SWISSPROT;Acc:Q96C90]	
2.87038	up	Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Source:Uniprot/SWISSPROT;Acc:P20807]	
2.93895	down	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Source:Uniprot/SWISSPROT;Acc:Q92844]	
2.95579	up	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Source:Uniprot/SWISSPROT;Acc:Q8TE77]	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/