Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 91 of 91 in total

Class	cellular component
Gene Ontology	nucleus

Ratio	Regulation	description	
1.89168	down	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Source:Uniprot/SWISSPROT;Acc:O95125]	
1.93995	up	Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Source:Uniprot/SWISSPROT;Acc:Q92785]	
1.98137	down	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Source:Uniprot/SWISSPROT;Acc:P35398]	
2.10428	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Source:Uniprot/SWISSPROT;Acc:P05412]	
2.12709	down	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Source:Uniprot/SWISSPROT;Acc:O95707]	
2.29381	up	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Source:Uniprot/SWISSPROT;Acc:O15265]	
2.31039	up	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Source:Uniprot/SWISSPROT;Acc:O94864]	
2.58329	down	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Source:Uniprot/SWISSPROT;Acc:Q9UL68]	
2.7017	up	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Source:Uniprot/SWISSPROT;Acc:Q8N2Z9]	
2.72371	up	Opa-interacting protein 5. [Source:Uniprot/SWISSPROT;Acc:O43482]	
2.83611	down	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Source:Uniprot/SWISSPROT;Acc:Q9UJW9]	
2.86298	up	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Source:Uniprot/SWISSPROT;Acc:Q16650]	
2.86965	up	RNA-binding protein 28 (RNA-binding motif protein 28). [Source:Uniprot/SWISSPROT;Acc:Q9NW13]	
2.87038	up	Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Source:Uniprot/SWISSPROT;Acc:P20807]	
2.91954	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Source:Uniprot/SWISSPROT;Acc:O95232]	
2.95579	up	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Source:Uniprot/SWISSPROT;Acc:Q8TE77]	
2.96739	up	Protein FRA10AC1. [Source:Uniprot/SWISSPROT;Acc:Q70Z53]	
3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Source:Uniprot/SWISSPROT;Acc:Q9Y2W7]	
3.29064	down	Transcription factor GATA-6 (GATA-binding factor 6). [Source:Uniprot/SWISSPROT;Acc:Q92908]	
3.35536	up	RNA polymerase-associated protein RTF1 homolog. [Source:Uniprot/SWISSPROT;Acc:Q92541]	
3.36725	up	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Source:Uniprot/SWISSPROT;Acc:Q15633]	
3.43019	down	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Source:Uniprot/SWISSPROT;Acc:O95926]	
3.48313	down	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Source:Uniprot/SWISSPROT;Acc:Q9GZN2]	
3.62109	down	Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Source:Uniprot/SWISSPROT;Acc:Q9UK76]	
3.70292	up	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Source:Uniprot/SWISSPROT;Acc:Q9UIU6]	
3.71868	down	Protein pelota homolog. [Source:Uniprot/SWISSPROT;Acc:Q9BRX2]	
3.81736	up	Transcription factor E2F3 (E2F-3). [Source:Uniprot/SWISSPROT;Acc:O00716]	
3.83977	down	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Source:Uniprot/SWISSPROT;Acc:Q8WYP5]	
4.04651	up	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Source:Uniprot/SWISSPROT;Acc:Q9UH99]	
4.14054	up	Protein odd-skipped-related 2. [Source:Uniprot/SWISSPROT;Acc:Q8N2R0]	
4.14557	down	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Source:Uniprot/SWISSPROT;Acc:Q8IV63]	
4.4149	down	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Source:Uniprot/SWISSPROT;Acc:P17861]	
4.49282	down	Enhancer of polycomb homolog 1. [Source:Uniprot/SWISSPROT;Acc:Q9H2F5]	
4.55177	up	Transcription factor SOX-14. [Source:Uniprot/SWISSPROT;Acc:O95416]	
4.55371	up	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Source:Uniprot/SWISSPROT;Acc:Q03431]	
5.32612	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Source:Uniprot/SWISSPROT;Acc:Q12968]	
5.81102	up	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Source:Uniprot/SWISSPROT;Acc:Q96JY6]	
5.83544	down	Nucleoplasmin-2. [Source:Uniprot/SWISSPROT;Acc:Q86SE8]	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/