MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2251 to 2300 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
2.65068	NULL	serine-type endopeptidase activity	molecular function
2.69364	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	anterior/posterior pattern formation	biological process
		central nervous system development
		electron transport
		endoplasmic reticulum	cellular component
		heme binding	molecular function
		iron ion binding
		membrane	cellular component
		metabolic process	biological process
		metal ion binding	molecular function
		microsome	cellular component
		monooxygenase activity	molecular function
		neural crest cell development	biological process
		oxygen binding	molecular function
		retinoic acid 4-hydroxylase activity
		retinoic acid metabolic process	biological process
		retinoic acid receptor signaling pathway
2.7017	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	chromosome	cellular component
		chromosome organization and biogenesis (sensu Eukaryota)	biological process
		chromosome, pericentric region	cellular component
		DNA binding	molecular function
		extracellular region	cellular component
		G-protein signaling, adenylate cyclase inhibiting pathway	biological process
		G-protein-coupled receptor binding	molecular function
		hormone activity
		neuropeptide hormone activity
		nucleosome	cellular component
		nucleosome assembly	biological process
		nucleus	cellular component
		soluble fraction
		synaptic transmission	biological process
2.70687	Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	calcium ion binding	molecular function
		homoiothermy	biological process
		ice binding	molecular function
		intracellular	cellular component
		response to freezing	biological process
		ribosome	cellular component
		structural constituent of ribosome	molecular function
		translation	biological process
2.72371	Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	Cajal body	cellular component
		cell communication	biological process
		cellular_component	cellular component
		chromatin
		chromocenter
		nucleus
		protein binding	molecular function
2.75048	SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	centrosome	cellular component
		centrosome duplication	biological process
		spindle	cellular component
		spindle assembly	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.