Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 2667 in total
Ratio	Regulation	description	Class	Gene Ontology	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	biological process	defense response	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	biological process	humoral immune response	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	biological process	ubiquitin cycle	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	cellular component	cytoplasm	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	cellular component	nucleus	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	molecular function	catalytic activity	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	molecular function	cofactor binding	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	molecular function	DNA binding	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Source:Uniprot/SWISSPROT;Acc:Q9GZZ9]	molecular function	translation regulator activity	
7.45006	down	MAP7 domain containing 1 [Source:RefSeq_peptide;Acc:NP_060537]	biological process	G-protein coupled receptor protein signaling pathway	
7.45006	down	MAP7 domain containing 1 [Source:RefSeq_peptide;Acc:NP_060537]	cellular component	integral to membrane	
7.45006	down	MAP7 domain containing 1 [Source:RefSeq_peptide;Acc:NP_060537]	molecular function	histamine receptor activity	
7.45006	down	MAP7 domain containing 1 [Source:RefSeq_peptide;Acc:NP_060537]	molecular function	structural constituent of cell wall	
7.27043	up	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Source:Uniprot/SWISSPROT;Acc:Q9BQP9]	molecular function	lipid binding	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	biological process	transcription	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	biological process	transcription from RNA polymerase III promoter	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	cellular component	DNA-directed RNA polymerase III complex	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	cellular component	nucleoplasm	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	cellular component	nucleus	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	molecular function	DNA-directed RNA polymerase activity	
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535]	molecular function	protein binding	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	biological process	protein amino acid phosphorylation	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	ATP binding	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	magnesium ion binding	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	nucleotide binding	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	protein kinase activity	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	protein serine/threonine kinase activity	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	protein-tyrosine kinase activity	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	molecular function	transferase activity	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	apoptosis	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	intracellular signaling cascade	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	negative regulation of cell growth	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	regulation of transcription, DNA-dependent	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	response to stress	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	transcription	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	cellular component	cytoplasm	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	cellular component	nucleus	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	molecular function	metal ion binding	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	molecular function	protein binding	
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81]	molecular function	zinc ion binding	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	biological process	axonogenesis	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	biological process	beta-tubulin folding	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	biological process	microtubule cytoskeleton organization and biogenesis	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	biological process	protein folding	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	biological process	protein modification process	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	cellular component	cytoplasm	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	cellular component	cytoskeleton	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	cellular component	microtubule	
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813]	molecular function	chaperone binding	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.
- http://analysis.yellowcouch.org/