Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Maximum Ratio Minimum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 43 of 43 in total

Class	molecular function
Gene Ontology	nucleotide binding

Ratio	Regulation	description	
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	
1.19117	up	Ras-related GTP-binding protein D (Rag D). [Source:Uniprot/SWISSPROT;Acc:Q9NQL2]	
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Source:Uniprot/SWISSPROT;Acc:Q9GZY0]	
1.20619	down	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Source:Uniprot/SWISSPROT;Acc:Q13733]	
1.21657	up	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Source:Uniprot/SWISSPROT;Acc:Q99719]	
1.21705	up	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Source:Uniprot/SWISSPROT;Acc:P78371]	
1.22178	up	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Source:Uniprot/SWISSPROT;Acc:O94921]	
1.22502	up	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Source:Uniprot/SWISSPROT;Acc:Q99758]	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	
1.24114	down	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	
1.24964	down	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Source:Uniprot/SWISSPROT;Acc:Q8NHH9]	
1.25808	up	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Source:Uniprot/SWISSPROT;Acc:Q9P2D1]	
1.30142	down	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Source:Uniprot/SWISSPROT;Acc:P22607]	
1.30802	down	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Source:Uniprot/SWISSPROT;Acc:O15438]	
1.34969	up	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Source:Uniprot/SWISSPROT;Acc:P27448]	
1.39878	up	ATPase family AAA domain-containing protein 2B. [Source:Uniprot/SWISSPROT;Acc:Q9ULI0]	
1.40602	up	GTP-binding protein SAR1a (COPII-associated small GTPase). [Source:Uniprot/SWISSPROT;Acc:Q9NR31]	
1.42264	up	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Source:Uniprot/SWISSPROT;Acc:Q9BWF3]	
1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Source:Uniprot/SWISSPROT;Acc:P30291]	
1.59763	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Source:Uniprot/SWISSPROT;Acc:Q8WVN8]	
1.60746	down	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Source:Uniprot/SWISSPROT;Acc:Q8TD26]	
1.61673	up	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Source:Uniprot/SWISSPROT;Acc:Q6P2M8]	
1.63945	up	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Source:Uniprot/SWISSPROT;Acc:P31152]	
1.65835	down	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Source:Uniprot/SWISSPROT;Acc:P57772]	
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Source:Uniprot/SWISSPROT;Acc:Q9H1R3]	
1.73211	down	Antigen KI-67. [Source:Uniprot/SWISSPROT;Acc:P46013]	
1.78439	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Source:Uniprot/SWISSPROT;Acc:Q14839]	
1.7961	up	RAS-like, family 11, member A [Source:RefSeq_peptide;Acc:NP_996563]	
1.81557	down	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Source:Uniprot/SWISSPROT;Acc:Q9ULG1]	
1.89308	up	Ras-related protein Rab-36. [Source:Uniprot/SWISSPROT;Acc:O95755]	
1.95876	up	Ras-related protein Rab-17. [Source:Uniprot/SWISSPROT;Acc:Q9H0T7]	
2.20843	up	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Source:Uniprot/SWISSPROT;Acc:P07947]	
2.25955	down	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Source:Uniprot/SWISSPROT;Acc:Q9BW92]	
2.44552	down	Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Source:Uniprot/SWISSPROT;Acc:O95837]	
2.86965	up	RNA-binding protein 28 (RNA-binding motif protein 28). [Source:Uniprot/SWISSPROT;Acc:Q9NW13]	
3.06659	down	ATP-binding domain 1 family member B. [Source:Uniprot/SWISSPROT;Acc:Q9H9Y4]	
3.21581	up	NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Source:Uniprot/SWISSPROT;Acc:Q86UW6]	
3.48558	up	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Source:Uniprot/SWISSPROT;Acc:P54753]	
3.64872	up	GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Source:Uniprot/SWISSPROT;Acc:Q96D21]	
4.14557	down	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Source:Uniprot/SWISSPROT;Acc:Q8IV63]	
5.31521	up	Rho-related BTB domain-containing protein 1. [Source:Uniprot/SWISSPROT;Acc:O94844]	
5.53059	up	rab and DnaJ domain containing [Source:RefSeq_peptide;Acc:NP_057628]	
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Source:Uniprot/SWISSPROT;Acc:Q6ZWH5]	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/