MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 948 in total

Regulation  : down
Class  : biological process

Ratio	description	Gene Ontology
1.11083	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	neurotransmitter transport
1.11956	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	retrograde vesicle-mediated transport, Golgi to ER
1.1243	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	regulation of transcription, DNA-dependent
		transcription
1.13541	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	blood coagulation
		cell adhesion
		regulation of growth
1.14311	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	negative regulation of protein kinase activity
		protein targeting
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
1.1611	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	electron transport
		signal transduction
1.18096	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	anagen
		blood pressure regulation
		cell motility
		cyclooxygenase pathway
		electron transport
		fatty acid biosynthetic process
		negative regulation of cell proliferation
		regulation of inflammatory response
		regulation of progression through cell cycle
		response to oxidative stress
1.18821	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	cytokine and chemokine mediated signaling pathway
		respiratory gaseous exchange
		signal transduction
1.19134	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	cell-cell signaling
		determination of left/right symmetry
		proteolysis
		zygotic determination of anterior/posterior axis, embryo
1.19212	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	hormone biosynthetic process
		signal transduction
		thyroid hormone generation
1.20481	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	biological_process
		generation of precursor metabolites and energy
		ovarian follicle development
		sexual reproduction
1.20619	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	ATP hydrolysis coupled proton transport
		cation transport
		hydrogen ion homeostasis
		metabolic process
		monovalent inorganic cation transport
		potassium ion transport
		proton transport
		sodium ion transport
		sperm motility
		transport
1.20924	Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	alcohol metabolic process
		embryonic eye morphogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.