MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	zinc ion binding	molecular function
			U12-dependent spliceosome	cellular component
			RNA splicing	biological process
			RNA binding	molecular function
			ribonucleoprotein complex	cellular component
			rhodopsin-like receptor activity	molecular function
			nucleus	cellular component
			nucleotide binding	molecular function
			nucleic acid binding
			metal ion binding
			integral to membrane	cellular component
			G-protein coupled receptor protein signaling pathway	biological process
1.08658	down	pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]	protein binding	molecular function
1.10233	up	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	cytoskeleton	cellular component
			cytoplasm
			cell cycle arrest	biological process
1.10831		Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	multicellular organismal development
			collagen binding	molecular function
1.10867		Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	terminal button	cellular component
			signal transduction	biological process
			positive regulation of transcription
			positive regulation of hormone secretion
			positive regulation of growth hormone secretion
			positive regulation of cAMP metabolic process
			positive regulation of body size
			hormone activity	molecular function
			growth hormone-releasing hormone receptor binding
			growth hormone-releasing hormone activity
			growth hormone secretion	biological process
			G-protein signaling, adenylate cyclase activating pathway
			extracellular region	cellular component
			elevation of cytosolic calcium ion concentration	biological process
			cell-cell signaling
			adenohypophysis development
1.10889		Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	transcription factor activity	molecular function
			transcription	biological process
			sequence-specific DNA binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			protein dimerization activity	molecular function
			nucleus	cellular component
			cytoplasm
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	transporter activity	molecular function
			symporter activity
			plasma membrane	cellular component
			neurotransmitter:sodium symporter activity	molecular function
			neurotransmitter transport	biological process
			membrane	cellular component
			integral to plasma membrane
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	translational initiation	biological process
			translation initiation factor activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.