Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 50 of 74 in total
Class  : cellular component
Gene Ontology  : integral to membrane
Ratio
Regulation
description
7.45006 down MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]
5.61927 RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]
5.19755 up Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]
4.67988 Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]
4.62042 down Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]
4.55371 up Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
4.05743 Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]
4.04651 Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
3.89584 Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]
3.76904 Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]
3.54928 down Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]
3.52215 Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]
3.41415 up Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]
3.39764 down Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]
3.31364 up Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]
3.14866 Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]
3.07625 down Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]
2.88235 Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
2.88128 CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]
2.86538 up Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]
2.85383 down Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]
2.79087 leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]
2.57202 up Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]
2.54508 Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
2.48474 BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]
1.98149 CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
1.96673 Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]
1.93863 Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
1.86433 CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]
1.83601 coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]
1.82063 down Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]
1.80942 Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]
1.76994 ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]
1.75846 Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]
1.75026 up Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]
1.72628 down Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]
1.69658 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]
1.6384 up Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]
1.63713 Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]
1.61987 Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
1.60746 down Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
1.60668 up Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]
1.54317 Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]
1.50206 LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]
1.4628 Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]
1.45148 Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]
1.40749 collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
1.40451 down COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]
1.37801 up Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Uniprot/SWISSPROT;Acc:Q9HCC8]
1.36911 down Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/