MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 1166 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.18096	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	biological process	anagen
			blood pressure regulation
			cell motility
			cyclooxygenase pathway
			electron transport
			fatty acid biosynthetic process
			negative regulation of cell proliferation
			regulation of inflammatory response
			regulation of progression through cell cycle
			response to oxidative stress
		cellular component	caveolar membrane
			cytoplasm
			endoplasmic reticulum
			membrane
			microsome
			nucleus
			protein complex
		molecular function	heme binding
			iron ion binding
			metal ion binding
			oxidoreductase activity
			oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
			peroxidase activity
			prostaglandin-endoperoxide synthase activity
			protein binding
1.18141	Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]		kinase activity
			transferase activity
1.18821	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	biological process	cytokine and chemokine mediated signaling pathway
			respiratory gaseous exchange
			signal transduction
		cellular component	granulocyte macrophage colony-stimulating factor receptor complex
			integral to membrane
			membrane
		molecular function	hematopoietin/interferon-class (D200-domain) cytokine receptor activity
			interleukin receptor activity
			interleukin-3 receptor activity
			interleukin-5 receptor activity
			receptor activity
1.19134	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	biological process	cell-cell signaling
			determination of left/right symmetry
			proteolysis
			zygotic determination of anterior/posterior axis, embryo
		cellular component	endoplasmic reticulum
			intracellular
			membrane
		molecular function	calcium ion binding
			nucleic acid binding
			peptidase activity
			subtilase activity
			zinc ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.