MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
3.54928	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	molecular function	glycerophosphodiester phosphodiesterase activity
			hydrolase activity
3.62109	Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	cellular component	nucleus
3.66058	olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]		extracellular matrix
			membrane
		molecular function	extracellular matrix binding
			latrotoxin receptor activity
			protein homodimerization activity
3.71868	Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]	biological process	translation
		cellular component	nucleus
		molecular function	protein binding
3.83977	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	biological process	multicellular organismal development
			regulation of transcription
			transcription
		cellular component	cytoplasm
			nuclear matrix
			nucleus
		molecular function	DNA binding
			transcription factor activity
3.99682	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	biological process	cell adhesion
			protein amino acid phosphorylation
		cellular component	membrane
		molecular function	ATP binding
			GPI anchor binding
			interleukin-1 receptor activity
			protein binding
			vascular endothelial growth factor receptor activity
4.14557	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	biological process	protein amino acid phosphorylation
		cellular component	nucleus
		molecular function	ATP binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			transferase activity
4.21401	Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	cellular component	membrane
4.40797	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	biological process	alcohol metabolic process
			carbohydrate metabolic process
			metabolic process
			neuropeptide signaling pathway
		cellular component	mitochondrion
		molecular function	aldehyde dehydrogenase (NAD) activity
			aldehyde dehydrogenase [NAD(P)+] activity
			electron carrier activity
			neuropeptide hormone activity
			oxidoreductase activity
4.4149	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	biological process	immune response
			regulation of transcription
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.