MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1851 to 1900 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	5.53059	up	molecular function	heat shock protein binding
				nucleotide binding
				protein binding
Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	1.49923	down	biological process	blood vessel development
				cell-cell adhesion
				platelet-derived growth factor receptor signaling pathway
				regulation of small GTPase mediated signal transduction
				signal transduction
				small GTPase mediated signal transduction
				transmembrane receptor protein tyrosine kinase signaling pathway
			cellular component	intracellular
			molecular function	guanyl-nucleotide exchange factor activity
				protein binding
RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	1.7961	up	biological process	protein transport
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				nucleotide binding
Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	1.19117		biological process	G-protein coupled receptor protein signaling pathway
				transport
			cellular component	cytoplasm
				nucleus
			molecular function	GTP binding
				guanyl nucleotide binding
				nucleotide binding
				protein binding
				signal transducer activity
Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]	1.95876		biological process	intracellular protein transport
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]	1.89308		biological process	intracellular protein transport
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	Golgi apparatus
				intracellular
				membrane
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	4.03725		biological process	dephosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.