MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2001 to 2050 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.83611	down	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	biological process	negative regulation of cell growth
				positive regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	protein binding
				transcriptional activator activity
2.8521	up	transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]	biological process	ion transport
			cellular component	integral to plasma membrane
				membrane
				membrane fraction
			molecular function	calcium channel activity
				ion channel activity
2.85383	down	Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	cellular component	integral to membrane
				membrane
2.86298	up	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	biological process	brain development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	DNA binding
				ligand-dependent nuclear receptor activity
				transcription factor activity
2.86538		Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]	biological process	G-protein coupled receptor protein signaling pathway
				sensory perception of smell
			cellular component	integral to membrane
			molecular function	cannabinoid receptor activity
				olfactory receptor activity
				receptor activity
				rhodopsin-like receptor activity
2.86965		RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	biological process	DNA topological change
			cellular component	chromosome
				nucleus
			molecular function	ATP binding
				DNA binding
				DNA topoisomerase (ATP-hydrolyzing) activity
				nucleic acid binding
				nucleotide binding
				RNA binding
2.87038		Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	biological process	muscle development
				proteolysis
				response to calcium ion
				response to drug
				sarcomere organization
			cellular component	cytoplasm
				intracellular
				nucleus
			molecular function	calcium ion binding
				calpain activity
				cysteine-type endopeptidase activity
				peptidase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.