MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

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Showing element 2501 to 2550 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
3.89584	cell communication	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	biological process
	integral to membrane		cellular component
	membrane
	membrane fraction
	molecular_function		molecular function
	Wnt receptor signaling pathway		biological process
4.03725	cytoplasm	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	cellular component
	dephosphorylation		biological process
	hydrolase activity		molecular function
	integral to plasma membrane		cellular component
	membrane
	phosphoric monoester hydrolase activity		molecular function
	protein amino acid dephosphorylation		biological process
	protein homodimerization activity		molecular function
	protein tyrosine phosphatase activity
	receptor activity
	soluble fraction		cellular component
	transmembrane receptor protein tyrosine phosphatase activity		molecular function
	transmembrane receptor protein tyrosine phosphatase signaling pathway		biological process
4.04651	condensed nuclear chromosome	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]	cellular component
	endosome
	integral to membrane
	membrane
	microtubule binding		molecular function
	mitotic spindle organization and biogenesis		biological process
	nuclear chromosome, telomeric region		cellular component
	nuclear envelope
	nuclear membrane organization and biogenesis		biological process
	nuclear migration
	nucleus		cellular component
	protein binding		molecular function
	protein dimerization activity
	regulation of transcription, DNA-dependent		biological process
	sequence-specific DNA binding		molecular function
	transcription factor activity
4.05743	integral to membrane	Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]	cellular component
	membrane
	response to stimulus		biological process
	sensory perception of sound
	visual perception
4.07995	cytoplasmic vesicle	AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	cellular component
	Golgi apparatus
	insulin receptor signaling pathway		biological process
	intracellular protein transport
	membrane		cellular component
	membrane coat
	membrane coat adaptor complex
	protein binding		molecular function
	protein complex assembly		biological process
	protein transporter activity		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.