MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 1031 in total

Regulation  : down
Class  : molecular function

Ratio	description	Gene Ontology
1.08658	pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]	protein binding
1.11083	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	neurotransmitter:sodium symporter activity
		symporter activity
		transporter activity
1.11956	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	molecular_function
1.1243	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	DNA binding
		metal ion binding
		nucleic acid binding
		zinc ion binding
1.13541	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	calcium ion binding
		protein binding
		structural molecule activity
		transmembrane receptor activity
1.14311	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	insulin-like growth factor receptor binding
		protein domain specific binding
		protein kinase C binding
		protein kinase C inhibitor activity
1.1611	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	electron carrier activity
		enzyme activator activity
		guanylate cyclase activator activity
		hormone activity
1.18096	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	heme binding
		iron ion binding
		metal ion binding
		oxidoreductase activity
		oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
		peroxidase activity
		prostaglandin-endoperoxide synthase activity
		protein binding
1.18141	Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]	kinase activity
		transferase activity
1.18821	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	hematopoietin/interferon-class (D200-domain) cytokine receptor activity
		interleukin receptor activity
		interleukin-3 receptor activity
		interleukin-5 receptor activity
		receptor activity
1.19134	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	calcium ion binding
		nucleic acid binding
		peptidase activity
		subtilase activity
		zinc ion binding
1.19212	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	hormone activity
1.20481	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	growth factor activity
		neuropeptide hormone activity
1.20619	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	ATP binding
		ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
		catalytic activity
		GABA-B receptor activity
		hydrolase activity
		hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.