Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 103 in total

Class	molecular function
Gene Ontology	protein binding

Ratio	Regulation	description	
1.08658	down	pyrin and HIN domain family, member 1 alpha 1 isoform [Source:RefSeq_peptide;Acc:NP_689714]	
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Source:Uniprot/SWISSPROT;Acc:Q99435]	
1.15279	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Source:Uniprot/SWISSPROT;Acc:Q9NZ53]	
1.16499	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	
1.16823	up	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Source:Uniprot/SWISSPROT;Acc:Q13309]	
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Source:Uniprot/SWISSPROT;Acc:P35354]	
1.18711	up	NULL	
1.19117	up	Ras-related GTP-binding protein D (Rag D). [Source:Uniprot/SWISSPROT;Acc:Q9NQL2]	
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Source:Uniprot/SWISSPROT;Acc:Q9GZY0]	
1.19545	up	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Source:Uniprot/SWISSPROT;Acc:O00115]	
1.21657	up	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Source:Uniprot/SWISSPROT;Acc:Q99719]	
1.21698	up	Kelch-like protein 34. [Source:Uniprot/SWISSPROT;Acc:Q8N239]	
1.21705	up	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Source:Uniprot/SWISSPROT;Acc:P78371]	
1.21871	down	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Source:Uniprot/SWISSPROT;Acc:Q13323]	
1.22178	up	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Source:Uniprot/SWISSPROT;Acc:O94921]	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	
1.24964	down	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Source:Uniprot/SWISSPROT;Acc:Q8NHH9]	
1.25147	up	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Source:Uniprot/SWISSPROT;Acc:P42081]	
1.2734	up	Neurexin-2-alpha precursor (Neurexin II-alpha). [Source:Uniprot/SWISSPROT;Acc:Q9P2S2]	
1.27696	down	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Source:Uniprot/SWISSPROT;Acc:Q5MJ70]	
1.27802	down	Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Source:Uniprot/SWISSPROT;Acc:O15479]	
1.28319	up	Autophagy-related protein 10 (APG10-like). [Source:Uniprot/SWISSPROT;Acc:Q9H0Y0]	
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Source:Uniprot/SWISSPROT;Acc:Q13207]	
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Source:Uniprot/SWISSPROT;Acc:O75122]	
1.30207	down	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Source:Uniprot/SWISSPROT;Acc:Q5SW96]	
1.30869	down	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Source:Uniprot/SWISSPROT;Acc:Q96EP1]	
1.31489	down	Tripartite motif-containing protein 58 (Protein BIA2). [Source:Uniprot/SWISSPROT;Acc:Q8NG06]	
1.33465	up	T-box transcription factor TBX5 (T-box protein 5). [Source:Uniprot/SWISSPROT;Acc:Q99593]	
1.33817	down	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Source:Uniprot/SWISSPROT;Acc:Q9H0R8]	
1.34969	up	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Source:Uniprot/SWISSPROT;Acc:P27448]	
1.35022	up	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Source:Uniprot/SWISSPROT;Acc:O15527]	
1.35125	up	Geminin. [Source:Uniprot/SWISSPROT;Acc:O75496]	
1.36997	up	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Source:Uniprot/SWISSPROT;Acc:Q8N264]	
1.40093	up	NULL	
1.42215	down	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Source:Uniprot/SWISSPROT;Acc:P31645]	
1.44789	up	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	
1.45148	up	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	
1.45635	up	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	
1.4628	up	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Source:Uniprot/SWISSPROT;Acc:Q9NQS3]	
1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Source:Uniprot/SWISSPROT;Acc:P30291]	
1.48389	down	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Source:Uniprot/SWISSPROT;Acc:P49790]	
1.49271	down	Cullin-4B (CUL-4B). [Source:Uniprot/SWISSPROT;Acc:Q13620]	
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Source:Uniprot/SWISSPROT;Acc:P12643]	
1.49923	down	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Source:Uniprot/SWISSPROT;Acc:Q13905]	
1.50284	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Source:Uniprot/SWISSPROT;Acc:P59780]	
1.50715	down	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Source:Uniprot/SWISSPROT;Acc:Q969U6]	
1.58045	down	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Source:Uniprot/SWISSPROT;Acc:P56589]	
1.59177	up	Transgelin-2 (SM22-alpha homolog). [Source:Uniprot/SWISSPROT;Acc:P37802]	
1.61347	down	Calmodulin-like protein 5 (Calmodulin-like skin protein). [Source:Uniprot/SWISSPROT;Acc:Q9NZT1]	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/