MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2001 to 2050 of 2667 in total

description	Ratio	Gene Ontology	Regulation	Class
Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]	4.04651	nuclear envelope	up	cellular component
		nuclear membrane organization and biogenesis		biological process
		nuclear migration
		nucleus		cellular component
		protein binding		molecular function
		protein dimerization activity
		regulation of transcription, DNA-dependent		biological process
		sequence-specific DNA binding		molecular function
		transcription factor activity
Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	4.49844	extracellular space	down	cellular component
		hormone activity		molecular function
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	1.65835	cytoplasm		cellular component
		GTP binding		molecular function
		GTPase activity
		nucleotide binding
		nucleus		cellular component
		selenocysteine incorporation		biological process
		translation elongation factor activity		molecular function
		translational elongation		biological process
		tRNA binding		molecular function
Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	1.21657	cell cycle	up	biological process
		cytokinesis
		GTP binding		molecular function
		GTPase activity
		nucleotide binding
		plasma membrane		cellular component
		positive regulation of exocytosis		biological process
		protein binding		molecular function
		regulation of exocytosis		biological process
		small GTPase mediated signal transduction
		structural molecule activity		molecular function
		synaptic vesicle		cellular component
		synaptic vesicle targeting		biological process
		synaptosome		cellular component
		syntaxin binding		molecular function
Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	6.50865	ATP binding
		magnesium ion binding
		nucleotide binding
		protein amino acid phosphorylation		biological process
		protein kinase activity		molecular function
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		transferase activity
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	1.22178	ATP binding
		cytoplasm		cellular component
		cytosol
		heme binding		molecular function
		nucleotide binding
		nucleus		cellular component
		protein amino acid phosphorylation		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.