MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1801 to 1850 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.25955	down	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	molecular function	ATP binding
				ligase activity
				nucleotide binding
				threonine-tRNA ligase activity
2.27115		RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]	cellular component	cell junction
				membrane
				synapse
2.2866	up	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade
				protein amino acid dephosphorylation
			cellular component	membrane fraction
				neuron projection
				protein serine/threonine phosphatase complex
				voltage-gated calcium channel complex
			molecular function	catalytic activity
				hydrolase activity
				magnesium ion binding
				manganese ion binding
				protein binding
				protein C-terminus binding
				protein phosphatase type 2C activity
				protein serine/threonine phosphatase activity
				signal transducer activity
2.29381		Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	biological process	cell death
				nuclear organization and biogenesis
				visual perception
			cellular component	cytoplasm
				intracellular
				nucleus
			molecular function	chromatin binding
				protein binding
				zinc ion binding
2.2939		Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	biological process	organelle organization and biogenesis
				pigmentation
			cellular component	cytoplasm
2.31039		STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]	biological process	maintenance of protein localization in nucleus
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	protein binding
2.31699	down	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	biological process	protein amino acid dephosphorylation
			cellular component	cytoplasm
				protein phosphatase type 2A complex
			molecular function	hydrolase activity
				iron ion binding
				manganese ion binding
				metal ion binding
				phosphoprotein phosphatase activity
				protein binding
				protein phosphatase type 2A activity
2.33107		F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]	biological process	ubiquitin cycle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.