MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 993 to 1042 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
3.54799	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	GTPase activity	molecular function
		protein binding
		signal transducer activity
		signal transduction	biological process
3.54928	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	cytoplasm	cellular component
		glycerol metabolic process	biological process
		glycerophosphodiester phosphodiesterase activity	molecular function
		hydrolase activity
		integral to membrane	cellular component
		membrane
3.62109	Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	nucleus
3.66058	olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]	extracellular matrix
		extracellular matrix binding	molecular function
		latrotoxin receptor activity
		membrane	cellular component
		protein homodimerization activity	molecular function
3.71868	Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]	nucleus	cellular component
		protein binding	molecular function
		translation	biological process
3.83977	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	cytoplasm	cellular component
		DNA binding	molecular function
		multicellular organismal development	biological process
		nuclear matrix	cellular component
		nucleus
		regulation of transcription	biological process
		transcription
		transcription factor activity	molecular function
3.99682	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	ATP binding
		cell adhesion	biological process
		GPI anchor binding	molecular function
		interleukin-1 receptor activity
		membrane	cellular component
		protein amino acid phosphorylation	biological process
		protein binding	molecular function
		vascular endothelial growth factor receptor activity
4.14557	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	ATP binding
		nucleotide binding
		nucleus	cellular component
		protein amino acid phosphorylation	biological process
		protein kinase activity	molecular function
		protein serine/threonine kinase activity
		transferase activity
4.21401	Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	membrane	cellular component
4.40797	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	alcohol metabolic process	biological process
		aldehyde dehydrogenase (NAD) activity	molecular function
		aldehyde dehydrogenase [NAD(P)+] activity
		carbohydrate metabolic process	biological process
		electron carrier activity	molecular function
		metabolic process	biological process
		mitochondrion	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.