MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 940 to 989 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	1.11083	biological process	neurotransmitter transport
		cellular component	integral to plasma membrane
			membrane
			plasma membrane
		molecular function	neurotransmitter:sodium symporter activity
			symporter activity
			transporter activity
Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	1.42215	biological process	monoamine transport
			neurotransmitter transport
			neurotransmitter uptake
			serotonin transport
		cellular component	integral to plasma membrane
			membrane
		molecular function	monoamine transporter activity
			neurotransmitter:sodium symporter activity
			protein binding
			serotonin transporter activity
			serotonin:sodium symporter activity
			symporter activity
Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	1.20619	biological process	ATP hydrolysis coupled proton transport
			cation transport
			hydrogen ion homeostasis
			metabolic process
			monovalent inorganic cation transport
			potassium ion transport
			proton transport
			sodium ion transport
			sperm motility
			transport
		cellular component	integral to membrane
			membrane
			sodium:potassium-exchanging ATPase complex
		molecular function	ATP binding
			ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
			catalytic activity
			GABA-B receptor activity
			hydrolase activity
			hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
			magnesium ion binding
			monovalent inorganic cation transporter activity
			nucleotide binding
			potassium ion binding
			sodium ion binding
			sodium:potassium-exchanging ATPase activity
Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	1.27696	biological process	cell cycle
			G1/S transition of mitotic cell cycle
			multicellular organismal development
			positive regulation of cell proliferation
			positive regulation of cyclin-dependent protein kinase activity
			protein amino acid dephosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.