MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 851 to 900 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	1.81557	molecular function	nucleic acid binding
			nucleotide binding
pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]	1.08658		protein binding
Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	4.71132	biological process	glycolysis
			response to other organism
		cellular component	cellular_component
		molecular function	magnesium ion binding
			potassium ion binding
			pyruvate kinase activity
			transferase activity
Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	1.49923	biological process	blood vessel development
			cell-cell adhesion
			platelet-derived growth factor receptor signaling pathway
			regulation of small GTPase mediated signal transduction
			signal transduction
			small GTPase mediated signal transduction
			transmembrane receptor protein tyrosine kinase signaling pathway
		cellular component	intracellular
		molecular function	guanyl-nucleotide exchange factor activity
			protein binding
Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	1.80858	biological process	signal transduction
		cellular component	intracellular
		molecular function	protein binding
			small GTPase regulator activity
Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	2.12709	biological process	rRNA processing
			tRNA processing
		cellular component	nucleus
			ribonuclease MRP complex
			ribonuclease P complex
		molecular function	hydrolase activity
			identical protein binding
			ribonuclease activity
			ribonuclease P activity
			RNA binding
RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]	2.27115	cellular component	cell junction
			membrane
			synapse
RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	5.61927	biological process	transport
		cellular component	integral to membrane
			membrane
		molecular function	metal ion binding
			nucleoside transporter activity
			protein binding
			zinc ion binding
Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	4.49844	cellular component	extracellular space
		molecular function	hormone activity
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	1.65835	biological process	selenocysteine incorporation
			translational elongation
		cellular component	cytoplasm
			nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.