MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 850 to 899 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
2.58329	nucleus	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	cellular component
	regulation of transcription, DNA-dependent		biological process
	transcription
	transcription factor activity		molecular function
	zinc ion binding
2.61135	DNA damage response, detection of DNA damage	28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	biological process
	mitochondrial small ribosomal subunit		cellular component
	mitochondrion
	peptide biosynthetic process		biological process
	ribonucleoprotein complex		cellular component
2.75593	protein modification process	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	biological process
2.79087	defense response	leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]
	integral to membrane		cellular component
	membrane
	protein binding		molecular function
2.83611	negative regulation of cell growth	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	biological process
	nucleus		cellular component
	positive regulation of transcription		biological process
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process
	transcription
	transcriptional activator activity		molecular function
2.85383	integral to membrane	Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	cellular component
	membrane
2.88128	integral to membrane	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]
	membrane
	sugar binding		molecular function
2.88235	anion exchanger activity	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
	anion transport		biological process
	antiporter activity		molecular function
	inorganic anion exchanger activity
	integral to membrane		cellular component
	integral to plasma membrane
	membrane
	membrane fraction
2.93895	cytoplasm	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]
	I-kappaB kinase/NF-kappaB cascade		biological process
	metal ion binding		molecular function
	protein binding
	signal transduction		biological process
	zinc ion binding		molecular function
3.00923	acetyltransferase activity	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]
	arylamine N-acetyltransferase activity
	cytoplasm		cellular component
	metabolic process		biological process
	transferase activity		molecular function
3.05037	calcium ion binding	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]
	cell adhesion		biological process
	extracellular region		cellular component
	heparin binding		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.