MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 840 to 889 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	1.82311	down	biological process	fibroblast growth factor receptor signaling pathway
				glial cell differentiation
				nervous system development
				regulation of progression through cell cycle
			cellular component	extracellular space
			molecular function	growth factor activity
Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	1.30142		biological process	cell growth
				fibroblast growth factor receptor signaling pathway
				forebrain development
				hair cell differentiation
				inner ear development
				JAK-STAT cascade
				MAPKKK cascade
				morphogenesis of an epithelium
				negative regulation of epithelial cell proliferation
				positive regulation of apoptosis
				positive regulation of cell differentiation
				positive regulation of peptidyl-tyrosine phosphorylation
				positive regulation of protein ubiquitination
				protein amino acid phosphorylation
				sensory perception of sound
				skeletal development
			cellular component	integral to membrane
				integral to plasma membrane
				internal side of plasma membrane
				lysosome
				membrane
				perinuclear region of cytoplasm
			molecular function	ATP binding
				fibroblast growth factor receptor activity
				identical protein binding
				interleukin-1 receptor activity
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				receptor activity
				transferase activity
Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3). [Uniprot/SWISSPROT;Acc:Q8TAT2]	1.18263	up		growth factor binding
Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	1.57088		biological process	caudate nucleus development
				putamen development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	metal ion binding
				nucleic acid binding
				protein homodimerization activity
				sequence-specific DNA binding
				transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.