MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 793 to 842 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.30802	down	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]	molecular function	transporter activity
1.30869		E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	biological process	cell cycle
				cell division
				mitosis
				mitotic cell cycle
				mitotic checkpoint
				protein polyubiquitination
				ubiquitin cycle
				ubiquitin-dependent protein catabolic process
			cellular component	cellular_component
				nucleus
			molecular function	ligase activity
				metal ion binding
				protein binding
				ubiquitin-protein ligase activity
				zinc ion binding
1.31489		Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	cellular component	intracellular
			molecular function	metal ion binding
				protein binding
				zinc ion binding
1.31661	up	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]	biological process	anion transport
				cytochrome complex assembly
				excretion
				heme transport
				sulfate transport
				transport
			cellular component	apical plasma membrane
				brush border membrane
				integral to membrane
				membrane
				membrane fraction
			molecular function	anion exchanger activity
				antiporter activity
				chloride ion binding
				heme transporter activity
				sulfate porter activity
				transcription cofactor activity
				transcription factor activity
				transporter activity
1.31895		Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]		receptor activity
1.32602	down	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	biological process	protein metabolic process
			molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
1.33329	up	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	biological process	carbohydrate metabolic process
				glycoprotein catabolic process
				metabolic process
				protein modification process
			cellular component	lysosome
			molecular function	beta-mannosidase activity
				cation binding
				hydrolase activity, hydrolyzing O-glycosyl compounds

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.