MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 793 to 842 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
2.16131	39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	cellular component	large ribosomal subunit
			mitochondrion
			ribosome
		molecular function	structural constituent of ribosome
2.25955	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	biological process	threonyl-tRNA aminoacylation
			translation
			tRNA aminoacylation for protein translation
		cellular component	cytoplasm
			mitochondrion
		molecular function	aminoacyl-tRNA ligase activity
			ATP binding
			ligase activity
			nucleotide binding
			threonine-tRNA ligase activity
2.27115	RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]	cellular component	cell junction
			membrane
			synapse
2.31699	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	biological process	protein amino acid dephosphorylation
		cellular component	cytoplasm
			protein phosphatase type 2A complex
		molecular function	hydrolase activity
			iron ion binding
			manganese ion binding
			metal ion binding
			phosphoprotein phosphatase activity
			protein binding
			protein phosphatase type 2A activity
2.33107	F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]	biological process	ubiquitin cycle
		cellular component	SCF ubiquitin ligase complex
		molecular function	protein binding
2.44552	Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	biological process	G-protein coupled receptor protein signaling pathway
			protein amino acid ADP-ribosylation
			signal transduction
		cellular component	heterotrimeric G-protein complex
			plasma membrane
		molecular function	GTP binding
			GTPase activity
			guanyl nucleotide binding
			nucleotide binding
			signal transducer activity
2.45383	40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	biological process	translation
		cellular component	cytosolic small ribosomal subunit (sensu Eukaryota)
			intracellular
			ribosome
			small ribosomal subunit
		molecular function	RNA binding
			structural constituent of ribosome
2.51088	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	biological process	lipid metabolic process
			transport
		molecular function	binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.