MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 743 to 792 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.30142	down	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	cellular component	perinuclear region of cytoplasm
			molecular function	ATP binding
				fibroblast growth factor receptor activity
				identical protein binding
				interleukin-1 receptor activity
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				receptor activity
				transferase activity
1.30207		Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]	biological process	cholesterol homeostasis
				cholesterol metabolic process
				endocytosis
				lipid metabolic process
				positive regulation of receptor mediated endocytosis
				regulation of protein binding
				steroid metabolic process
			cellular component	AP-1 adaptor complex
				AP-2 adaptor complex
				basal plasma membrane
				cytoplasm
				cytosol
				early endosome
			molecular function	clathrin binding
				phosphotyrosine binding
				protein binding
				protein binding, bridging
				protein C-terminus binding
				receptor signaling complex scaffold activity
				transport accessory protein activity
1.30407	up	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	biological process	axonogenesis
				multicellular organismal development
				regulation of transcription, DNA-dependent
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
1.30802	down	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]	biological process	transport
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				membrane fraction
			molecular function	ATP binding
				ATPase activity
				ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity
				nucleotide binding
				organic anion transporter activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.