MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 693 to 742 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.75846	lysosomal membrane	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	cellular component
	lysosome
	membrane
	transport		biological process
1.76583	aminopeptidase activity	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	molecular function
	antigen processing and presentation of endogenous peptide antigen via MHC class I		biological process
	blood pressure regulation
	endoplasmic reticulum lumen		cellular component
	membrane alanyl aminopeptidase activity		molecular function
	metallopeptidase activity
	N-terminal arginine aminopeptidase activity
	N-terminal lysine aminopeptidase activity
	proteolysis		biological process
	zinc ion binding		molecular function
1.76994	cell adhesion	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process
	integral to membrane		cellular component
	metal ion binding		molecular function
	metalloendopeptidase activity
	metallopeptidase activity
	myoblast fusion		biological process
	plasma membrane		cellular component
	protein binding		molecular function
	proteolysis		biological process
	zinc ion binding		molecular function
1.80858	intracellular	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	cellular component
	protein binding		molecular function
	signal transduction		biological process
	small GTPase regulator activity		molecular function
1.80942	integral to membrane	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	cellular component
	membrane
1.81557	ATP binding	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	molecular function
	DNA binding
	helicase activity
	homoiothermy		biological process
	hydrolase activity		molecular function
	ice binding
	nucleic acid binding
	nucleotide binding
	nucleus		cellular component
	response to freezing		biological process
1.82063	integral to membrane	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	cellular component
	membrane
1.82311	cell proliferation	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	biological process
	cell-cell signaling
	extracellular space		cellular component
	fibroblast growth factor receptor signaling pathway		biological process
	glial cell differentiation
	growth factor activity		molecular function
	nervous system development		biological process
	regulation of progression through cell cycle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.