MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 690 to 739 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	cellular component	cytoplasm
				cytoplasmic microtubule
				cytoskeleton
				Golgi apparatus
				kinetochore microtubule
			molecular function	binding
				galactoside 2-alpha-L-fucosyltransferase activity
				microtubule binding
				microtubule plus-end binding
				protein binding
1.29238		Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]		FAD binding
				oxidoreductase activity
1.29424	down	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	biological process	ciliary or flagellar motility
			cellular component	flagellin-based flagellum
			molecular function	calcium ion binding
1.2984		nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	biological process	cytokinesis after mitosis
				establishment of mitotic spindle localization
				mitotic chromosome condensation
				positive regulation of mitosis
			cellular component	nucleolus
				spindle microtubule
			molecular function	microtubule binding
1.29952		Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	biological process	regulation of progression through cell cycle
			cellular component	cytoplasm
				nucleus
1.30082		CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	biological process	regulation of global transcription from RNA polymerase II promoter
				regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	cytoplasm
				nucleus
			molecular function	RNA polymerase II transcription mediator activity
				transcription regulator activity
1.30142		Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	biological process	cell growth
				fibroblast growth factor receptor signaling pathway
				forebrain development
				hair cell differentiation
				inner ear development
				JAK-STAT cascade
				MAPKKK cascade
				morphogenesis of an epithelium
				negative regulation of epithelial cell proliferation
				positive regulation of apoptosis
				positive regulation of cell differentiation
				positive regulation of peptidyl-tyrosine phosphorylation
				positive regulation of protein ubiquitination
				protein amino acid phosphorylation
				sensory perception of sound
				skeletal development
			cellular component	integral to membrane
				integral to plasma membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.