MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 690 to 739 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.75846	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	biological process	L-cystine transport
			transport
		cellular component	integral to membrane
			lysosomal membrane
			lysosome
			membrane
		molecular function	L-cystine transporter activity
1.76583	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I
			blood pressure regulation
			proteolysis
		cellular component	endoplasmic reticulum lumen
		molecular function	aminopeptidase activity
			membrane alanyl aminopeptidase activity
			metallopeptidase activity
			N-terminal arginine aminopeptidase activity
			N-terminal lysine aminopeptidase activity
			zinc ion binding
1.76994	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process	cell adhesion
			myoblast fusion
			proteolysis
		cellular component	integral to membrane
			plasma membrane
		molecular function	metal ion binding
			metalloendopeptidase activity
			metallopeptidase activity
			protein binding
			zinc ion binding
1.80858	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	biological process	signal transduction
		cellular component	intracellular
		molecular function	protein binding
			small GTPase regulator activity
1.80942	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	cellular component	integral to membrane
			membrane
1.81557	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	biological process	homoiothermy
			response to freezing
		cellular component	nucleus
		molecular function	ATP binding
			DNA binding
			helicase activity
			hydrolase activity
			ice binding
			nucleic acid binding
			nucleotide binding
1.82063	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	cellular component	integral to membrane
			membrane
1.82311	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	biological process	cell proliferation
			cell-cell signaling
			fibroblast growth factor receptor signaling pathway
			glial cell differentiation
			nervous system development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.