MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Gene Ontology	Accession	Class	Gene	Ratio	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 593 to 642 of 2667 in total

description	Regulation	Gene Ontology	Class	Ratio
Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	down	ATP binding	molecular function	3.99682
		cell adhesion	biological process
		GPI anchor binding	molecular function
		interleukin-1 receptor activity
		membrane	cellular component
		protein amino acid phosphorylation	biological process
		protein binding	molecular function
		vascular endothelial growth factor receptor activity
COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]		integral to membrane	cellular component	1.40451
		membrane
		mitochondrion
Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]		cell cycle	biological process	1.49271
		cellular_component	cellular component
		DNA repair	biological process
		molecular_function	molecular function
		protein binding
		ubiquitin cycle	biological process
Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	up	cell cycle		1.45635
		cell division
		cytoplasm	cellular component
		female pronucleus
		male pronucleus
		mitosis	biological process
		mitotic G2 checkpoint
		nucleus	cellular component
		positive regulation of transcription	biological process
		protein binding	molecular function
		regulation of cyclin-dependent protein kinase activity	biological process
		regulation of progression through cell cycle
Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	down			1.36349
		spermatogenesis
Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	up	amino acid metabolic process		1.19539
		catalytic activity	molecular function
		cysteine desulfurase activity
		cytoplasm	cellular component
		cytosol
		lyase activity	molecular function
		metabolic process	biological process
		mitochondrion	cellular component
		nucleus
		protein complex assembly	biological process
		pyridoxal phosphate binding	molecular function
		sulfur amino acid metabolic process	biological process
		transaminase activity	molecular function
		transferase activity
Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]		biological_process	biological process	1.63639
		cellular_component	cellular component
		cytoplasmic vesicle
		Golgi apparatus
		Golgi-associated vesicle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.