MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 551 to 600 of 948 in total

Class  : biological process

Ratio	Regulation	Gene Ontology	description
1.683	down	rRNA processing	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
1.693		metabolic process	CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]
1.69345	up	regulation of transcription	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
		regulation of transcription, DNA-dependent
1.69658	down	protein amino acid glycosylation	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]
1.69856	up	neuromuscular synaptic transmission	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]
		protein amino acid phosphorylation
1.72628	down	DNA repair	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]
1.72656		ER overload response	protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]
		response to hydrogen peroxide
		response to oxidative stress
1.73211		cell cycle	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
		cell proliferation
		meiosis
		regulation of progression through cell cycle
1.73291	up	potassium ion transport	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]
1.75026		axon ensheathment	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]
		calcium-independent cell-cell adhesion
		cell adhesion
		spermatogenesis
1.75846	down	amino acid metabolic process	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]
		L-cystine transport
		transport
1.76583		antigen processing and presentation of endogenous peptide antigen via MHC class I	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]
		blood pressure regulation
		proteolysis
1.76994		cell adhesion	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]
		myoblast fusion
		proteolysis
1.78439	up	chromatin assembly or disassembly	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
		chromatin modification
		chromosome organization and biogenesis (sensu Eukaryota)
		intracellular signaling cascade
		regulation of transcription from RNA polymerase II promoter
		transcription
1.79094		signal transduction	Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]
1.7961		protein transport	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]
		small GTPase mediated signal transduction
1.80858	down	signal transduction	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]
1.81557		homoiothermy	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]
		response to freezing
1.82311		cell proliferation	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]
		cell-cell signaling
		fibroblast growth factor receptor signaling pathway
		glial cell differentiation
		nervous system development
		regulation of progression through cell cycle
1.83496	up	ceramide metabolic process	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]
		signal transduction
1.83601		G-protein coupled receptor protein signaling pathway	coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.