MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	1.23845	biological process	response to sterol depletion
			steroid metabolic process
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
		molecular function	protein binding
Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	2.08208	biological process	hyaluronan metabolic process
		cellular component	extracellular region
		molecular function	serine-type endopeptidase inhibitor activity
Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	1.43088	biological process	carotenoid biosynthetic process
			cholesterol biosynthetic process
			isoprenoid biosynthetic process
		cellular component	peroxisome
		molecular function	hydrolase activity
			isomerase activity
			isopentenyl-diphosphate delta-isomerase activity
			magnesium ion binding
Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	3.39764	biological process	biological_process
			muscle development
		cellular component	integral to membrane
			junctional membrane complex
			membrane
			microsome
			sarcoplasmic reticulum
			Z disc
		molecular function	molecular_function
			structural constituent of muscle
Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	1.69153	cellular component	intermediate filament
Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]	1.18141	molecular function	kinase activity
			transferase activity
leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]	2.79087	biological process	defense response
		cellular component	integral to membrane
			membrane
		molecular function	protein binding
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	4.62042	biological process	protein amino acid N-linked glycosylation
			visual perception
		cellular component	integral to membrane
			integral to plasma membrane
			membrane
			plasma membrane
leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	1.76583	biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I
			blood pressure regulation
			proteolysis
		cellular component	endoplasmic reticulum lumen
		molecular function	aminopeptidase activity
			membrane alanyl aminopeptidase activity
			metallopeptidase activity
			N-terminal arginine aminopeptidase activity
			N-terminal lysine aminopeptidase activity
			zinc ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.