MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 51 to 100 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	1.20924	biological process	nucleus accumbens development
			optic cup morphogenesis involved in camera-type eye development
			positive regulation of apoptosis
			retinoic acid metabolic process
		cellular component	cytoplasm
		molecular function	3-chloroallyl aldehyde dehydrogenase activity
			aldehyde dehydrogenase [NAD(P)+] activity
			oxidoreductase activity
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	4.40797	biological process	alcohol metabolic process
			carbohydrate metabolic process
			metabolic process
			neuropeptide signaling pathway
		cellular component	mitochondrion
		molecular function	aldehyde dehydrogenase (NAD) activity
			aldehyde dehydrogenase [NAD(P)+] activity
			electron carrier activity
			neuropeptide hormone activity
			oxidoreductase activity
Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	2.88235	biological process	anion transport
		cellular component	integral to membrane
			integral to plasma membrane
			membrane
			membrane fraction
		molecular function	anion exchanger activity
			antiporter activity
			inorganic anion exchanger activity
Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	4.93372	biological process	intracellular signaling cascade
Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	1.73211		cell cycle
			cell proliferation
			meiosis
			regulation of progression through cell cycle
		cellular component	chromosome, pericentric region
			condensed chromosome
			cytoplasm
			nucleolus
			nucleus
		molecular function	ATP binding
			nucleotide binding
			protein binding
AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	1.50284	biological process	intracellular protein transport
			protein complex assembly
			transport
			vesicle-mediated transport
		cellular component	cytoplasmic vesicle
			Golgi apparatus
			membrane
			membrane coat
		molecular function	protein binding
			protein transporter activity
Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	3.00923	biological process	metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.