MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	1.28805	down	metalloendopeptidase activity	molecular function
			metallopeptidase activity
			peptidase activity
			proteinaceous extracellular matrix	cellular component
			proteolysis	biological process
			zinc ion binding	molecular function
ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	2.45875	up	extracellular matrix	cellular component
			intracellular
			metal ion binding	molecular function
			metalloendopeptidase activity
			metallopeptidase activity
			nucleic acid binding
			peptidase activity
			proteinaceous extracellular matrix	cellular component
			proteolysis	biological process
			zinc ion binding	molecular function
Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	5.19755		fatty acid oxidation	biological process
			hormone binding	molecular function
			hormone-mediated signaling	biological process
			identical protein binding	molecular function
			integral to membrane	cellular component
			lipid metabolic process	biological process
			membrane	cellular component
			protein heterodimerization activity	molecular function
			receptor activity
Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	1.20924	down	3-chloroallyl aldehyde dehydrogenase activity
			alcohol metabolic process	biological process
			aldehyde dehydrogenase [NAD(P)+] activity	molecular function
			cytoplasm	cellular component
			embryonic eye morphogenesis	biological process
			lipid metabolic process
			metabolic process
			nucleus accumbens development
			optic cup morphogenesis involved in camera-type eye development
			oxidoreductase activity	molecular function
			positive regulation of apoptosis	biological process
			retinoic acid metabolic process
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	4.40797		alcohol metabolic process
			aldehyde dehydrogenase (NAD) activity	molecular function
			aldehyde dehydrogenase [NAD(P)+] activity
			carbohydrate metabolic process	biological process
			electron carrier activity	molecular function
			metabolic process	biological process
			mitochondrion	cellular component
			neuropeptide hormone activity	molecular function
			neuropeptide signaling pathway	biological process
			oxidoreductase activity	molecular function
Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	2.49031	up	nervous system development	biological process
			protein binding	molecular function
			protein transport	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.