MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	description	Gene Ontology	Gene	Class	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 440 to 489 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.22502	up	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	ATP binding	molecular function
			ATPase activity
			ATPase activity, coupled to transmembrane movement of substances
			integral to membrane	cellular component
			lamellar body
			membrane fraction
			nucleoside-triphosphatase activity	molecular function
			nucleotide binding
			plasma membrane	cellular component
			response to drug	biological process
			transport
			transporter activity	molecular function
1.22528		protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	dephosphorylation	biological process
			hydrolase activity	molecular function
			phosphoric monoester hydrolase activity
			protein amino acid dephosphorylation	biological process
			protein tyrosine phosphatase activity	molecular function
			protein tyrosine/serine/threonine phosphatase activity
1.22576		Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	DNA binding
			metal ion binding
			methyl-CpG binding
			negative regulation of transcription	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription corepressor activity	molecular function
			transcription factor activity
			transcription from RNA polymerase II promoter	biological process
			zinc ion binding	molecular function
1.22694		Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	type I hypersensitivity	biological process
1.23668	down	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	actin binding	molecular function
			ATP binding
			biological_process	biological process
			calmodulin binding	molecular function
			motor activity
			myosin complex	cellular component
			nucleoside-triphosphatase activity	molecular function
			nucleotide binding
			unconventional myosin complex	cellular component
1.23783		Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	cytoplasm
			GTPase activator activity	molecular function
			intracellular	cellular component
			metal ion binding	molecular function
			phosphatidylinositol-3,4,5-triphosphate binding
			regulation of GTPase activity	biological process
			signal transduction
			zinc ion binding	molecular function
1.23845		Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	cell proliferation	biological process
			cholesterol metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.