MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 401 to 450 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.21657	up	molecular function	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	syntaxin binding
1.21698		biological process	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	electron transport
				metabolic process
		molecular function		oxidoreductase activity
				protein binding
1.21705		biological process	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	cellular protein metabolic process
				protein amino acid phosphorylation
				protein folding
				regulation of progression through cell cycle
		cellular component		chaperonin-containing T-complex
				cytoplasm
				cytosol
		molecular function		ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				unfolded protein binding
1.21871	down	biological process	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	apoptotic program
				induction of apoptosis
				regulation of apoptosis
		cellular component		integral to membrane
				membrane
				mitochondrial envelope
		molecular function		protein binding
1.22047	up	biological process	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	mitosis
		cellular component		nucleus
1.22178		biological process	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	protein amino acid phosphorylation
		cellular component		cytoplasm
				cytosol
				nucleus
		molecular function		ATP binding
				heme binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
				transition metal ion binding
1.22502		biological process	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	response to drug
				transport
		cellular component		integral to membrane
				lamellar body
				membrane fraction
				plasma membrane
		molecular function		ATP binding
				ATPase activity
				ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity
				nucleotide binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.