MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 2551 to 2600 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	1.60668	molecular function	identical protein binding
			ion channel activity
transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	1.16158	biological process	calcium ion transport
			ion transport
		cellular component	membrane
		molecular function	calcium channel activity
			ion channel activity
transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]	2.8521	biological process	ion transport
		cellular component	integral to plasma membrane
			membrane
			membrane fraction
		molecular function	calcium channel activity
			ion channel activity
Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	1.14915	biological process	cell-cell signaling
			signal transduction
			transport
		cellular component	integral to membrane
			membrane
		molecular function	receptor binding
Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	3.14866	cellular component	integral to membrane
			membrane
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	1.62709	biological process	dephosphorylation
			protein amino acid dephosphorylation
		cellular component	cytoplasmic vesicle
		molecular function	hydrolase activity
			phosphoric monoester hydrolase activity
			protein tyrosine phosphatase activity
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	1.07618	biological process	G-protein coupled receptor protein signaling pathway
			RNA splicing
		cellular component	integral to membrane
			nucleus
			ribonucleoprotein complex
			U12-dependent spliceosome
		molecular function	metal ion binding
			nucleic acid binding
			nucleotide binding
			rhodopsin-like receptor activity
			RNA binding
			zinc ion binding
Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	8.21788	biological process	defense response
			humoral immune response
			ubiquitin cycle
		cellular component	cytoplasm
			nucleus
		molecular function	catalytic activity
			cofactor binding
			DNA binding
			oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
			translation regulator activity
Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	1.49444	biological process	protein modification process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.