MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 250 to 299 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	1.49558	down	biological process	embryonic development
				epithelial to mesenchymal transition
				growth
				inflammatory response
				negative regulation of cell proliferation
				negative regulation of progression through cell cycle
				odontogenesis (sensu Vertebrata)
				organ morphogenesis
				osteoblast differentiation
				positive regulation of astrocyte differentiation
				positive regulation of ossification
				positive regulation of osteoblast differentiation
				regulation of transcription
				ureteric bud branching
			cellular component	extracellular region
				extracellular space
			molecular function	cytokine activity
				growth factor activity
				protein binding
				transforming growth factor beta receptor binding
BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	1.73291	up	biological process	potassium ion transport
			cellular component	membrane
				voltage-gated potassium channel complex
			molecular function	protein binding
				voltage-gated potassium channel activity
Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	1.24359	down	biological process	exocytosis
				protein transport
			cellular component	cell junction
				cytoplasmic vesicle
				membrane
				synapse
			molecular function	calcium ion binding
				lipid binding
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	1.61673	up	biological process	protein amino acid phosphorylation
			cellular component	cytoplasm
				nucleus
			molecular function	ATP binding
				calcium ion binding
				calmodulin binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	1.29424	down	biological process	ciliary or flagellar motility
			cellular component	flagellin-based flagellum
			molecular function	calcium ion binding
Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	1.61347		biological process	ciliary or flagellar motility
				epidermis development
				signal transduction

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.