MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Class	Regulation	description	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 2667 in total

Ratio	Gene Ontology	Class	Regulation	description
4.40797	neuropeptide hormone activity	molecular function	down	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]
	neuropeptide signaling pathway	biological process
	oxidoreductase activity	molecular function
4.4149	DNA binding			X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]
	immune response	biological process
	nucleus	cellular component
	protein dimerization activity	molecular function
	regulation of transcription	biological process
	regulation of transcription, DNA-dependent
	sequence-specific DNA binding	molecular function
	transcription	biological process
	transcription factor activity	molecular function
4.49282	chromatin modification	biological process		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]
	negative regulation of gene expression, epigenetic
	negative regulation of transcription from RNA polymerase II promoter
	nuclear membrane	cellular component
	nucleoplasm
	nucleus
	positive regulation of transcription from RNA polymerase II promoter	biological process
	regulation of cell growth
	regulation of transcription, DNA-dependent
	transcription
	transcriptional activator activity	molecular function
	transcriptional repressor activity
4.49844	extracellular space	cellular component		Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]
	hormone activity	molecular function
4.50619	apoptosis	biological process		Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]
	cytoplasm	cellular component
	cytoskeleton
	membrane
	phagocytosis	biological process
4.55177	chromatin	cellular component	up	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]
	DNA binding	molecular function
	establishment and/or maintenance of chromatin architecture	biological process
	nervous system development
	nucleus	cellular component
	regulation of transcription, DNA-dependent	biological process
	transcription
	transcription factor activity	molecular function
4.55371	cytoplasm	cellular component		Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
	G-protein coupled receptor activity	molecular function
	G-protein signaling, coupled to cyclic nucleotide second messenger	biological process
	integral to membrane	cellular component
	integral to plasma membrane
	membrane
	nucleus
	parathyroid hormone receptor activity	molecular function
	receptor activity
	signal transduction	biological process
	skeletal development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.