MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2151 to 2200 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
2.20843	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	biological process	glucose transport
			intracellular signaling cascade
			protein amino acid autophosphorylation
			protein amino acid phosphorylation
			protein modification process
		cellular component	cytoplasm
			membrane fraction
		molecular function	ATP binding
			nucleotide binding
			protein binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
2.2866	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade
			protein amino acid dephosphorylation
		cellular component	membrane fraction
			neuron projection
			protein serine/threonine phosphatase complex
			voltage-gated calcium channel complex
		molecular function	catalytic activity
			hydrolase activity
			magnesium ion binding
			manganese ion binding
			protein binding
			protein C-terminus binding
			protein phosphatase type 2C activity
			protein serine/threonine phosphatase activity
			signal transducer activity
2.29381	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	biological process	cell death
			nuclear organization and biogenesis
			visual perception
		cellular component	cytoplasm
			intracellular
			nucleus
		molecular function	chromatin binding
			protein binding
			zinc ion binding
2.2939	Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	biological process	organelle organization and biogenesis
			pigmentation
		cellular component	cytoplasm
2.31039	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]	biological process	maintenance of protein localization in nucleus
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus
		molecular function	protein binding
2.37788	Coiled-coil domain-containing protein 83. [Uniprot/SWISSPROT;Acc:Q8IWF9]	cellular component	viral capsid
		molecular function	structural molecule activity
2.43098	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	biological process	lipid transport
			steroid metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.