MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Gene	Class	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 2151 to 2200 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	down	1.20619	monovalent inorganic cation transport	biological process
			monovalent inorganic cation transporter activity	molecular function
			nucleotide binding
			potassium ion binding
			potassium ion transport	biological process
			proton transport
			sodium ion binding	molecular function
			sodium ion transport	biological process
			sodium:potassium-exchanging ATPase activity	molecular function
			sodium:potassium-exchanging ATPase complex	cellular component
			sperm motility	biological process
			transport
Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	up	1.10867	adenohypophysis development
			cell-cell signaling
			elevation of cytosolic calcium ion concentration
			extracellular region	cellular component
			G-protein signaling, adenylate cyclase activating pathway	biological process
			growth hormone secretion
			growth hormone-releasing hormone activity	molecular function
			growth hormone-releasing hormone receptor binding
			hormone activity
			positive regulation of body size	biological process
			positive regulation of cAMP metabolic process
			positive regulation of growth hormone secretion
			positive regulation of hormone secretion
			positive regulation of transcription
			signal transduction
			terminal button	cellular component
Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	down	1.27696	cell cycle	biological process
			G1/S transition of mitotic cell cycle
			multicellular organismal development
			nucleus	cellular component
			positive regulation of cell proliferation	biological process
			positive regulation of cyclin-dependent protein kinase activity
			protein amino acid dephosphorylation
			protein binding	molecular function
			protein kinase binding
			protein phosphatase type 1 activity
			regulation of progression through cell cycle	biological process
			response to DNA damage stimulus
Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	up	1.16363	integral to membrane	cellular component
			membrane
STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]		2.31039	maintenance of protein localization in nucleus	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]		3.03423	binding	molecular function
			kinetochore	cellular component
			mitosis	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.