MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	up	1.22178	protein binding	molecular function
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
			transition metal ion binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	down	4.14557	ATP binding
			nucleotide binding
			nucleus	cellular component
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]		2.31699	cytoplasm	cellular component
			hydrolase activity	molecular function
			iron ion binding
			manganese ion binding
			metal ion binding
			phosphoprotein phosphatase activity
			protein amino acid dephosphorylation	biological process
			protein binding	molecular function
			protein phosphatase type 2A activity
			protein phosphatase type 2A complex	cellular component
Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	up	1.59819	calcium ion binding	molecular function
			detection of stimulus during sensory perception	biological process
			hydrolase activity	molecular function
			iron ion binding
			manganese ion binding
			phosphoprotein phosphatase activity
			protein amino acid dephosphorylation	biological process
			protein serine/threonine phosphatase activity	molecular function
			response to stimulus	biological process
			visual perception
SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	down	2.83611	negative regulation of cell growth
			nucleus	cellular component
			positive regulation of transcription	biological process
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcriptional activator activity	molecular function
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	up	2.07532	cell junction	cellular component
			cytoplasm
			cytoskeletal anchoring	biological process
			dendrite	cellular component
			intracellular
			membrane fraction
			postsynaptic membrane
			protein binding	molecular function
			synapse	cellular component
Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]		7.27043	lipid binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.