MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1751 to 1800 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	1.66123	molecular function	nucleic acid binding
Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	3.89584	biological process	cell communication
			Wnt receptor signaling pathway
		cellular component	integral to membrane
			membrane
			membrane fraction
		molecular function	molecular_function
LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	1.50206	biological process	ceramide biosynthetic process
			lipid biosynthetic process
			regulation of transcription, DNA-dependent
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
			nucleus
		molecular function	sequence-specific DNA binding
			transcription factor activity
Lariat debranching enzyme (EC 3.1.-.-). [Uniprot/SWISSPROT;Acc:Q9UK59]	1.37411	biological process	mRNA processing
			nuclear mRNA splicing, via spliceosome
			RNA splicing, via transesterification reactions
		cellular component	nucleus
		molecular function	hydrolase activity
			hydrolase activity, acting on ester bonds
			metal ion binding
			RNA lariat debranching enzyme activity
LRRC44 protein. [Uniprot/SPTREMBL;Acc:Q6P5P7]	3.41794		protein binding
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	1.34969	biological process	protein amino acid phosphorylation
		molecular function	ATP binding
			nucleotide binding
			protein binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	1.20102	biological process	apoptosis
			cell cycle
			electron transport
			ion transport
			iron ion transport
		cellular component	endosome
			integral to membrane
			membrane
			plasma membrane
		molecular function	copper ion binding
			FAD binding
			ferric-chelate reductase activity
			iron ion binding
			metal ion binding
			oxidoreductase activity
Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	1.22576	biological process	negative regulation of transcription
			regulation of transcription, DNA-dependent

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.