MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1701 to 1750 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.96673	up	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	cellular component	integral to membrane
				membrane
				microsome
			molecular function	peptidase activity
				serine-type peptidase activity
1.98137	down	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	biological process	regulation of transcription, DNA-dependent
				signal transduction
				transcription
			cellular component	nucleus
			molecular function	DNA binding
				ligand-dependent nuclear receptor activity
				metal ion binding
				protein binding
				sequence-specific DNA binding
				steroid hormone receptor activity
				thyroid hormone receptor activity
				transcription factor activity
				zinc ion binding
1.98149	up	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	biological process	anti-apoptosis
				B cell differentiation
				B cell proliferation
				immune response
				inflammatory response
				isotype switching
				leukocyte adhesion
				platelet activation
				regulation of immunoglobulin secretion
			cellular component	extracellular space
				integral to membrane
				integral to plasma membrane
				membrane
				soluble fraction
			molecular function	CD40 receptor binding
				cytokine activity
				tumor necrosis factor receptor binding
2.07532		SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	biological process	cytoskeletal anchoring
			cellular component	cell junction
				cytoplasm
				dendrite
				intracellular
				membrane fraction
				postsynaptic membrane
				synapse
			molecular function	protein binding
2.08208	down	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	biological process	hyaluronan metabolic process
			cellular component	extracellular region
			molecular function	serine-type endopeptidase inhibitor activity
2.10428	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	biological process	cellular process
				leading edge cell differentiation
				negative regulation of protein amino acid autophosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.