MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1619 to 1668 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.83496	up	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	biological process	ceramide metabolic process
				signal transduction
			cellular component	cytoplasm
				soluble fraction
			molecular function	receptor signaling protein activity
1.83601		coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]	biological process	G-protein coupled receptor protein signaling pathway
			cellular component	integral to membrane
				membrane
				mitochondrion
1.86204	down	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	metal ion binding
				nucleic acid binding
				transcription factor activity
				zinc ion binding
1.86433	up	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]	biological process	cation transport
				chemotaxis
			cellular component	extracellular space
				integral to membrane
				membrane
			molecular function	ATP binding
				ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
				cytokine activity
1.89168	down	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]	biological process	lipid metabolic process
				negative regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	DNA binding
				metal ion binding
				nucleic acid binding
				specific RNA polymerase II transcription factor activity
				transcription factor activity
				zinc ion binding
1.89308	up	Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]	biological process	intracellular protein transport
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	Golgi apparatus
				intracellular
				membrane
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
1.93863		Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]	biological process	G-protein coupled receptor protein signaling pathway

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.