MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 151 to 200 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.16499	up	molecular function	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	zinc ion binding
1.16823		biological process	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	cell proliferation
				G1/S transition of mitotic cell cycle
				regulation of progression through cell cycle
				ubiquitin cycle
		molecular function		protein binding
1.16921		biological process	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	cell differentiation
				multicellular organismal development
				nervous system development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
		cellular component		nucleus
				transcription factor complex
		molecular function		DNA binding
				transcription cofactor activity
				transcription factor activity
				transcription regulator activity
1.17398		cellular component	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Uniprot/SWISSPROT;Acc:O75356]	endoplasmic reticulum
				integral to membrane
				membrane
		molecular function		calcium ion binding
				hydrolase activity
				magnesium ion binding
				nucleoside-diphosphatase activity
1.17693		biological process	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	biological_process
		cellular component		cellular_component
				cytoplasm
				membrane
		molecular function		lipid binding
				phosphatidylinositol binding
1.17859	down	cellular component	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	integral to membrane
				membrane
1.17879	up	biological process	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	inner ear morphogenesis
				ion transport
				potassium ion transport
				sensory perception of sound
		cellular component		membrane
				membrane fraction
				voltage-gated potassium channel complex
		molecular function		ion channel activity
				potassium ion binding
				voltage-gated ion channel activity
				voltage-gated potassium channel activity
1.18096	down	biological process	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	anagen
				blood pressure regulation
				cell motility
				cyclooxygenase pathway
				electron transport
				fatty acid biosynthetic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.